Targeting of newly synthesized proteins is an integral component
of protein synthesis.
In prokaryotes, targeting is usually achieved by an N-terminal
sequence of about 20 mostly hydrophobic amino acids.
In eukaryotes, targeting is more complex due to the large
number of different cellular compartments:
Nuclear targeting via the nuclear pore using
a nuclear localization signal.
ER targeting (secretory pathway) via
N-terminal signal sequences using SRPs with subsequent attachment
to the ER,
Followed by transport to the Golgi complex
Protein degradation of damaged or obsolete proteins is carried
by lysosomes, vesicles filled with degradating
in a ubiqutin-dependent process by specific proteases in
a large cytosolic complex called the proteasome.
Please report typos, errors etc. by EMAIL
(mention the title of this page).